Anastrozole 1

Anastrozole is a potent and selective nonsteroidal aromatase inhibitor. It is used for the treatment of hormone receptor-positive breast cancer in postmenopausal women, either as an adjuvant therapy following initial treatment with tamoxifen or as a first-line treatment option.

Unlike steroidal aromatase inhibitors, anastrozole does not bind to the estrogen receptor. Instead, it binds to and inactivates the aromatase enzyme, which is responsible for the conversion of androgens to estrogens in peripheral tissues. By blocking estrogen synthesis, anastrozole helps reduce the stimulation of estrogen-sensitive breast tumors, thereby slowing or preventing their growth.